JWJ-01-306 is a CRBN-recruiting ZBTB11 Molecular Glues degrader. JWJ-01-306 degrades ZBTB11 and reprograms cellular metabolism, thereby reducing the level of Oxidative Phosphorylation and the activity of the tricarboxylic acid cycle. JWJ-01-306 enhances the response of organoids to K-Ras inhibition. JWJ-01-306 inhibits the proliferation of pancreatic ductal adenocarcinoma cells and melanoma cells. JWJ-01-306 can be used in studies related to pancreatic ductal adenocarcinoma and melanoma[1][2].
Molecular Weight:
574.98
CAS Number:
[3069975-17-0]
Formula:
C28H26ClF3N4O4
Target:
Molecular Glues,Oxidative Phosphorylation
Application Notes:
MCE Product type: Reference compound1
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