ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 µM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization[1].
Molecular Weight:
513.67
CAS Number:
[3049802-32-3]
Formula:
C29H43N3O5
Target:
HDAC,VD/VDR
Application Notes:
MCE Product type: Reference compound1
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