Antitumor agent-174 (Compound 10) directly engages the N-terminal site of Hsp90 and promotes the degradation of beta-catenin, thereby suppressing the Wnt/beta-catenin signaling. Antitumor agent-174 effectively inhibits proliferation, induce S and G2/M phases arrest and block the clonogenic ability in CRC cells. Antitumor agent-174 down-regulates CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, and upregulaties P21 proteins. Antitumor agent-174 has significant anti-tumor efficacy against colorectal cancer (CRC) with excellent pharmacokinetics and low toxicity[1].
Molecular Weight:
357.28
Formula:
C20H18Cl2N2
Target:
CDK,c-Myc,HSP,Wnt,beta-catenin
Application Notes:
Reference compound
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