Poltheta-IN-4 is an orally active prodrug of a DNA polymerase theta (Poltheta) inhibitor with Kms of 3.7, 3.7 and 5.2 µM in human, mouse and rat recombinant alkaline phosphatases. Poltheta-IN-4 that inhibits Poltheta activity by targeting its ATP-dependent helicase domain. Poltheta-IN-4 demonstrates significant anti-tumor activity in multiple animal experiments. Poltheta-IN-4 can be used for the studies of breast cancer and ovarian cancer[1].
Molecular Weight:
501.84
Purity:
98.71
CAS Number:
[3043810-73-4]
Formula:
C17H17ClN5O7PS
Target:
DNA/RNA Synthesis
Application Notes:
Reference compound
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