AP-6 is a TMEM175 channel blocker with an IC50 value of 141 µM against human targets (under neutral pH conditions), and it exhibits selectivity over other 4-AP-sensitive potassium channels. AP-6 binds to the luminal entrance of the ion-permeable pathway of TMEM175, thereby blocking ion conduction and inhibiting the flow of potassium ions and protons through this channel. AP-6 is applicable to research related to Parkinsons disease[1].
Molecular Weight:
262.31
Purity:
99.84
CAS Number:
[1369963-51-8]
Formula:
C16H14N4
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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