JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-gamma and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1].
Molecular Weight:
316.31
Purity:
99.77
CAS Number:
[3079468-41-7]
Formula:
C19H12N2O3
Target:
TNF Receptor
Application Notes:
MCE Product type: Reference compound
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