GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1].
Molecular Weight:
432.38
Purity:
99.96
CAS Number:
[2924063-98-7]
Formula:
C20H18F2N4O5
Target:
EBI2/GPR183
Application Notes:
MCE Product type: Reference compound
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