PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 µM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect[1].
Molecular Weight:
953.52
Formula:
C50H61ClN8O9
Target:
Ferroptosis,Glutathione Peroxidase,PROTACs
Application Notes:
Reference compound
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