MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing celldeath by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-kappaB p65. MSA-2-Pt enhances tumor infiltration of CD4+ and CD8+ T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models[1].
Molecular Weight:
815.78
Formula:
C28H32N2O10PtS2
Target:
Apoptosis,IFNAR,IKK,NF-kappaB,STING
Application Notes:
MCE Product type: Reference compound
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