PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCgamma2-Ca2+-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model[1].
Molecular Weight:
885.99
Formula:
C46H52FN13O5
Target:
Btk,Nuclear Factor of activated T Cells (NFAT),PROTACs,RANKL/RANK
Application Notes:
MCE Product type: Reference compound
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