BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis[1].
Molecular Weight:
493.39
Purity:
99.46
CAS Number:
[3032487-31-0]
Formula:
C22H16F5N5O3
Target:
ADAMTS
Application Notes:
MCE Product type: Reference compound
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