BAL-0028 is a reversible inhibitor of NLRP3 activation with an IC50 value of 25 nM. BAL-0028 binds closely to the NACHT domain of the NLRP3 with KD values of 104-123 nM. BAL-0028 can inhibit the secretion of IL-1beta and has anti-inflammatory activity[1].
Molecular Weight:
403.45
Purity:
99.86
CAS Number:
[2842012-69-3]
Formula:
C24H22FN3O2
Target:
Interleukin Related,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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