BIO-7488 is an orally active, selective and blood-brain barrier permeable IRAK4 inhibitor, with an IC50 value of 0.5 nM. BIO-7488 inhibits the production of pro-inflammatory cytokines (IL-1beta, TNFalpha, IL-6) and demonstrates anti-inflammatory effects in both LPS (HY-D1056) and distal hypoxic-middle cerebral artery occlusion (DH-MCAO) ischemic stroke model. BIO-7488 can be used for the study of neuroinflammatory-related diseases, particularly ischemic stroke[1].
Molecular Weight:
447.49
Purity:
99.44
CAS Number:
[2573211-25-1]
Formula:
C23H25N7O3
Target:
IRAK
Application Notes:
MCE Product type: Reference compound1
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