FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1, with IC50s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML)[1].
Molecular Weight:
444.47
Formula:
C18H23F3N6O2S
Target:
Checkpoint Kinase (Chk),FLT3
Application Notes:
MCE Product type: Reference compound
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