MPD2 is a Cereblon-binding ligand-based PROTAC that degrades MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro protein levels in 293T cells in a time-dependent manner (DC50=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882),Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763))[1].
Molecular Weight:
973.12
Formula:
C51H68N6O13
Target:
PROTACs,SARS-CoV
Application Notes:
MCE Product type: Reference compound
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