IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits beta-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation[1][2].
Molecular Weight:
436.55
Purity:
99.94
CAS Number:
[2737274-49-4]
Formula:
C25H32N4O3
Target:
Arrestin,Calcium Channel,CCR,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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