LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC50 of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-kappaB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand (HY-14658))[1].
Molecular Weight:
744.75
Formula:
C39H36N8O8
Target:
IRAK,NF-kappaB,PROTACs
Application Notes:
MCE Product type: Reference compound1
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