(Rac)-NRL-1049 (dihydrochloride), CAS [[863638-93-1]] Preis auf Anfrage

Product Overview

• Article Name: (Rac)-NRL-1049 (dihydrochloride), CAS [[863638-93-1]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-162596A
• Supplier Catalog Number: HY-162596A
• Alternative Catalog Number: MCE-HY-162596A-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: (Rac)-BA-1049

Product Description

(Rac)-NRL-1049 is the racemic mixture of NRL-1049 (BA-1049 (free base)) (HY-162596). NRL-1049 is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations[1][2].

Product Properties

• Molecular Weight: 392.34
• CAS Number: [863638-93-1]
• Formula: C16H23Cl2N3O2S
• Target: ROCK

Application Notes

• Application Notes: MCE Product type: Reference compound