D-01 is a dual-targeting inhibitor of HIF-1alpha and EZH2 (IC50: 4.86 µM and 0.99 µM respectively). D-01 inhibits the expression of H3K27me3 protein. D-01 inhibits the migration, clone and the invasion of A549 cells, and also inhibits tube formation of HUVECs. D-01 can be used for research of lung cancer[1].
