AF-45 inhibits IRAK4 and IRAK1, with IC50s of 128 nM and 1765 nM. AF-45 inhibits the release of IL-6 and TNF-alpha in macrophages, with IC50s of 0.53-1.54 µM and 0.6-2.75 µM. AF-45 is also an inhibitor for NF-kappaB/MAPK signaling pathway. AF-45 exhibits anti-inflammatory activities against DSS-induced ulcerative colitis and Lipopolysaccharide (HY-D1056)-induced acute lung injury in mouse model. AF-45 exhibits good pharmacokinetic characteristics in rat models[1].
Molecular Weight:
379.45
Formula:
C22H25N3O3
Target:
IRAK,NF-kappaB,p38 MAPK,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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