SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC50 of 1.30 µM. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 µM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD50=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models[1].
Molecular Weight:
410.87
Purity:
99.57
CAS Number:
[3054715-45-3]
Formula:
C22H20ClFN4O
Target:
ClpP
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
