c-Met degrader-1 (Compound H11) is an orally active c-Met degrader (through the ubiquitin proteasome system). c-Met degrader-1 has anti-hepatocellular carcinoma activity (HCC) and inhibits tumor growth in MHCC97H xenografts. c-Met degrader-1 inhibits HCC cell growth, arrests cell cycle, and induces apoptosis. c-Met degrader-1 may overcome resistance to type Ib inhibitors[1].
Molecular Weight:
739.95
Formula:
C45H53N7O3
Target:
Apoptosis,c-Met/HGFR
Application Notes:
MCE Product type: Reference compound
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