MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARgamma, with an IC50 of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors[1].
Molecular Weight:
453.94
Purity:
99.87
CAS Number:
[2791417-66-6]
Formula:
C22H20ClN5O2S
Target:
EGFR,PI3K,PPAR
Application Notes:
MCE Product type: Reference compound
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