OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor[1].
Molecular Weight:
312.31
Purity:
99.80
CAS Number:
[2131210-15-4]
Formula:
C15H18F2N2O3
Target:
Molecular Glues,Phosphodiesterase (PDE)
Application Notes:
Reference compound
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