JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704)[1].
Molecular Weight:
518.71
CAS Number:
[2871774-93-3]
Formula:
C30H38N4O2S
Target:
Cytochrome P450,Ligands for Target Protein for PROTAC,Pregnane X Receptor (PXR)
Application Notes:
MCE Product type: Reference compound
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