Nivocasan (GS 9450, LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1beta cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK[1].
Molecular Weight:
415.41
CAS Number:
[908253-63-4]
Formula:
C21H22FN3O5
Target:
Caspase,Interleukin Related
Application Notes:
MCE Product type: Reference compound
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