ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1].
Molecular Weight:
395.46
Formula:
C24H21N5O
Target:
DYRK,Tau Protein
Application Notes:
MCE Product type: Reference compound1
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