Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABAA receptors and NaV1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED50 of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid (HY-N2309) with an IC50 of 113 µM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable[1].
Molecular Weight:
448.51
Formula:
C24H21FN4O2S
Target:
GABA Receptor,Sodium Channel
Application Notes:
MCE Product type: Reference compound1
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