IDH1/2-IN-1 (Compound 6b) serves as a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 µM and 1.6 µM, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia[1].
Molecular Weight:
580.62
Formula:
C26H28N8O6S
Target:
Apoptosis,Isocitrate Dehydrogenase (IDH)
Application Notes:
MCE Product type: Reference compound
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