TST1N-224 is a potent response regulator VraRC inhibitor. TST1N-224 can disrupt VraRC-DNA complex formation (IC50=60.2 µM). TST1N-224 exhibits interference with VraRC binding to its cognate DNA through a fast-on-fast-off binding mechanism (KD=23.4 µM). TST1N-224 predominantly interacts with the alpha9- and alpha10-helixes of the DNA-binding domain of VraR. TST1N-224 inhibits the growths of S. aureus (SA, MIC>126 µM), Methicillin-resistant S. aureus (MRSA, MIC>126 µM), and Vancomycin-intermediate S. aureus (VISA, MIC=63 µM). TST1N-224, an antimicrobial agent, evidently enhances the susceptibility of VISA to both Vancomycin (HY-B0671) and Methicillin (HY-B0974)[1].
Molecular Weight:
460.65
CAS Number:
[50566-97-7]
Formula:
C10H20O8S6
Target:
Antibiotic,Bacterial
Application Notes:
MCE Product type: Reference compound
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