BRD-810 is a potent and selective MCL1 inhibitor with a Kd of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2, Bcl-xL). BRD-810 effectively destroys the MCL1-BAK complex (IC50 = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis. BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors[1].
Molecular Weight:
703.24
Purity:
98.00
CAS Number:
[2329719-65-3]
Formula:
C39H44ClFN4O5
Target:
Apoptosis,Bcl-2 Family,Caspase
Application Notes:
MCE Product type: Reference compound1
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