WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRalpha Y849 and 5.8 nM for PDGFRbeta Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing alpha-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension[1].
Molecular Weight:
418.49
Purity:
99.41
CAS Number:
[2376694-72-1]
Formula:
C24H26N4O3
Target:
ERK,PDGFR
Application Notes:
MCE Product type: Reference compound
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