Lonaprisan (ZK 230211, BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect[1].
Molecular Weight:
508.52
CAS Number:
[211254-73-8]
Formula:
C28H29F5O3
Target:
Progesterone Receptor
Application Notes:
MCE Product type: Reference compound
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