BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent[1].
Molecular Weight:
252.70
Purity:
98.16
CAS Number:
[2198977-68-1]
Formula:
C12H13ClN2O2
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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