HDAC-IN-79 (compound 4) is an orally active dual xanthine oxidase-HDAC inhibitor (Xanthine oxidase: IC50=6.6 nM, HDAC1: IC50=134 nM, HDAC2: IC50=284 nM, HDAC3: IC50=173 nM, HDAC6: IC50=1.32 nM,), with significant in vivo anti-hyperuricemia and anti-tumor activities. HDAC-IN-79 is the most potent cell growth inhibitor (IC50=0.706 µM) of leukemia HL60 cells, induces apoptosis and autophagy, and can regulate the expression levels of signature biomarkers associated with intracellular HDAC inhibition[1].
Molecular Weight:
458.57
Formula:
C23H30N4O4S
Target:
Apoptosis,Autophagy,HDAC,Xanthine Oxidase
Application Notes:
MCE Product type: Reference compound
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