YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. YK-2168 inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes including MYC and Mcl1, and inhibits tumor growth in CDX mice models. YK-2168 can be used for the research of cancer, such as leukemia[1].
Molecular Weight:
315.80
Purity:
98.05
CAS Number:
[2571068-74-9]
Formula:
C16H18ClN5
Target:
Apoptosis,CDK,c-Myc
Application Notes:
MCE Product type: Reference compound
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