SILA-123 is a FLT3 inhibitor (FLT3-WT: IC50=2.1 nM, FLT3-ITD: IC50=1.0 nM). SILA-123 inhibits FLT3 phosphorylation and downstream signaling pathways, leading to apoptosis by arresting cell cycle progression at the G0/G1 phase. SILA-123 can be used in the study of acute myeloid leukemia[1].
Molecular Weight:
415.49
CAS Number:
[2911585-37-8]
Formula:
C24H25N5O2
Target:
Apoptosis,FLT3
Application Notes:
MCE Product type: Reference compound
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