JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein-protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC50 values of 39.6 nM and 4.28µM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis[1].
Molecular Weight:
610.57
Formula:
C33H37Cl2N3O4
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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