IA-14069 is an orally active tumor necrosis factor-alpha (TNF-alpha) inhibitor. IA-14069 binds directly to TNF-alpha and TNF-alpha-triggered signaling (p-IkappaBalpha and NF-kappaB p65) activities. Additionally, IA-14069 exerts a suppressive effect on Dextran sodium sulfate (HY-116282C) (DSS)-induced colitis. IA-14069 can be used for the research of Rheumatoid arthritis (RA) and inflammatory bowel disease (IBD)[1][2].
Molecular Weight:
392.78
Purity:
99.93
CAS Number:
[2271216-04-5]
Formula:
C20H15ClF2O4
Target:
NF-kappaB,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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