aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374)[1].
Molecular Weight:
867.85
Purity:
99.1
CAS Number:
[2412985-00-1]
Formula:
C46H39F2N9O7
Target:
DNA/RNA Synthesis,PROTACs
Application Notes:
MCE Product type: Reference compound
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