JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 µM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD+ in THP-1 human monocytes. JGB-1-155 attenuates TNFalpha-induced ROS in HT-22 cells [1].
Molecular Weight:
426.59
CAS Number:
[3011930-28-9]
Formula:
C26H38N2O3
Target:
NAMPT
Application Notes:
MCE Product type: Reference compound
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