SIRT4-IN-1

Product Overview

• Article Name: SIRT4-IN-1
• Biozol Catalog Number: MCE-HY-163316
• Supplier Catalog Number: HY-163316
• Alternative Catalog Number: MCE-HY-163316-5MG,MCE-HY-163316-25MG,MCE-HY-163316-10MG,MCE-HY-163316-10MMX1ML,MCE-HY-163316-50MG,MCE-HY-163316-100MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 µM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4s acyl binding site, and is noncompetitive with NAD+. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease[1].

Product Properties

• Molecular Weight: 503.53
• Purity: 98.75
• Formula: C19H13N5O6S3
• Target: Glutamate Dehydrogenase (GLDH),PDHK,Sirtuin

Application Notes

• Application Notes: MCE Product type: Reference compound