F44-A13 is an orally active and highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 µM. F44-A13 can optimize cholesterol metabolism and reduce its activity by inducing CYP7A1 expression. F44-A13 reduces levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in mouse models. F44-A13 can be used in the study of metabolic diseases associated with lipid disorders[1].
Molecular Weight:
544.71
Purity:
96.73
CAS Number:
[1338190-14-9]
Formula:
C28H40N4O5S
Target:
Cytochrome P450,FXR,PPAR,RAR/RXR,ROR
Application Notes:
MCE Product type: Reference compound1
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