Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 µM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties[1].
Molecular Weight:
510.42
Formula:
C24H16BrNO3S2
Target:
Aminoacyl-tRNA Synthetase,Parasite
Application Notes:
MCE Product type: Reference compound
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