BOLD-100 (NKP-1339, IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu[1].
Molecular Weight:
502.14
Purity:
95.20
CAS Number:
[197723-00-5]
Formula:
C14H12Cl4N4NaRu
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
Reference compound
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