AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability[1].
Molecular Weight:
331.36
Formula:
C16H14FN3O2S
Target:
Aryl Hydrocarbon Receptor,Dystrophin
Application Notes:
MCE Product type: Reference compound
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