Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as alpha-tubulin, beta-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 µM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model[1].
Molecular Weight:
825.26
Formula:
C27H32BF2I2N5O4S
Target:
Carbonic Anhydrase
Application Notes:
Reference compound
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