Antiproliferative agent-51 (Compound 18h) exhibits inhibitory efficacy against estrogen receptor alpha (ERalpha) mediated transcription, with an IC50 of 1.6 nM. Antiproliferative agent-51 inhibits the proliferation of cancer cell ZR-75, with an IC50 of 0.031 µM. Antiproliferative agent-51 exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
766.88
Formula:
C43H50N4O9
Target:
Estrogen Receptor/ERR
Application Notes:
Reference compound
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