Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib citrate also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3].
Molecular Weight:
664.70
Purity:
99.68
CAS Number:
[1228923-42-9]
Formula:
C34H40N4O10
Target:
FLT3,JAK
Application Notes:
Reference compound
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