CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 µM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 µM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].
Molecular Weight:
518.56
Formula:
C27H30N6O5
Target:
DNA Methyltransferase,HDAC
Application Notes:
MCE Product type: Reference compound
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